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Dimethylsulfoxide, DMSO: Comprehensive AI Reference + special tips

Guaranteed to save your life as it has mine

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u-dont-exist.com
Oct 25, 2025
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DMSO is an amazing substance with over 300 medical uses, especially arthritis, stroke, cancer, brain damage, mental illness, and sports/auto injuries. It must be in your first aid kit and you will most likely be using it on a regular basis. It’s saved me from countless doctors and hospitals. My father used it for decades before me also, for a wide range of problems.

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This miraculous panacea is at the very top of the charts on Substack medical blogs, with AMD’s articles on it getting thousands of comments. I posted a critique of one of AMD’s articles along with general critiques of AMD here. I will give a list of AMD DMSO articles at the end, as well as all the main DMSO books in PDF form, and all of this combined in a Gemini deep research convo. However, I wish to put my 2 cents in first, as there are certain uses that are less known, or should be especially highlighted:

DMSO:

  • Turns Bad Trips Good Instantly and Reverses Drug Overdose Brain Damage.

    DMSO is a super powerful neuroprotective agent (rivaled only by fullerenes in Zholy3O), and it works for nearly any kind of brain damage you can imagine. I and many people I know have discovered that when you’re having a bad trip, DMSO can almost always turn it into a good trip, instantly. If you overdose on whatever drugs and you feel brain damaged (like body functions going wild), DMSO also fixes this almost instantly (15mL in some juice may be enough, if not you can take more afterward). You can even just touch it with clean skin, which won’t give as much of a dose, but is super useful if you’re trying to help someone who doesn’t want to take any medicine. The more you take, the better it works. One time I took 15mL after 5 milligrams of LSD (a “thumbprint dose”) and I went from feeling really messed up to feeling better than ever, in a second. I would have added DMSO to my ZHoly2O formula, except that it just tastes so bad that probably nobody would use it.

  • Cures Mental Illnesses: There’s one main study done on this topic from 1967. DMSO worked better for psychiatric patients than all other psych meds at that time (slashing their psych ward stays in half), and it still does, although there’s no money for studying it more. It boosts the mood, calms, clears, and focuses the mind.

  • Nebulizing DMSO is amazing for lung inflammation and brain health. I wrote more about this here. There are no studies I can find on this topic (AMD has info on it but recommends ridiculously low strength of DMSO), but I know from personal experience nebulizing it myself and getting hundreds of friends to do so, that it’s safe and highly beneficial for non-smokers (for smokers it can bring the toxins from your lungs into your blood too quickly if you use a high concentration of DMSO, so instead you can try nebulizing Holy Water, as mentioned in ZHoly3O). I think 1 person said they didn’t react well. DMSO is also the only nontoxic solvent for vape carts (aside from terpenes, which work ok for cannabis vapes). When you nebulize it, it removes the toxins from your brain. If you keep nebulizing it for a while, once all the toxins are removed, you start getting a beautiful clear-headed blissful high which you can’t get with anything else except maybe Xenon gas.

    • Vaping DMSO is safe below 150C, although it smells of garlic. It is the only solvent, aside from certain terpenes, which is safe to vape. If you are making vape carts for DMT, etc, you should be using DMSO instead of neurotoxic PEG/PG (research). Unfortunately, many vape carts are not designed to work well with DMSO, so they can leak. Greenlightvapes G9 carts worked perfectly, but they are no longer sold. These DVP carts might be the next best.

  • Topical application for burns, scars, injuries, infections:
    Make sure to clean the skin first! Nothing else on Earth seems to have the power that DMSO has to heal burns, injuries, and subdermal infections (even systemic antibiotic drugs do not work nearly as well for those). If you smash you finger in a door, soaking it in DMSO will work a lot better than icing it. One friend had absolutely no swelling after soaking his smashed thumb in DMSO for a while, and it was almost all healed the next day. A friend of mine got the most severe burn of her life recently from holding a 500F skillet—no sign of burn the next morning after overnight aloe vera DMSO application. This actually is not unique info, but the next part is, and it’s connected to this:

    • Concentration of DMSO & duration of application matters a lot.
      Some so-called doctors, like AMD, give ridiculously low concentrations and doses of DMSO which will not do anything at all. You can tell if the DMSO is really penetrating your skin because you taste it in your mouth immediately and you feel it in your brain. It gives a clear, relaxed alert feeling. If you don’t feel the DMSO in your mouth and brain then it may be too dilute. Note that it dilutes itself if you leave it out without the cap on.
      I found that I needed close to 100% concentration of DMSO in order to treat a serious foot infection (which Drs tried but failed to treat). I had to keep the foot wrapped in DMSO (with plastic wrap) for days in order for it to fully remove the infection. Pure DMSO causes skin crenation (like you get from soaking fingers in water, but worse), which looks bad but goes away in a week without treatment.

      The upper body has more sensitive skin than the lower body, so you may need to dilute the DMSO a bit more for upper body. DMSO when undiluted can wrinkle the skin, which returns to normal in a week. If it causes itching that just means you should rinse it off fairly soon, but sometimes you do need to use a concentration strong enough to itch for a bit so it really does the job.

    • Can DMSO bring bacteria into the skin? DMSO can bring certain small molecules into the skin, but despite what AMD thinks, it won’t bring bacteria in unless the skin is broken. More importantly, at a concentration of about 80%, no bacteria can thrive in DMSO.

    • Clean your skin first: What you need to worry about with DMSO on the skin is mainly that it can bring in chemicals, like beauty products, etc.

  • Gut: As reported on AMD’s gut article which I critiqued, DMSO demonstrates some effectiveness in healing ulcers. DMSO enemas should be diluted enough that they won’t bring toxins from the colon into the blood. I would probably use 10% DMSO but it depends on the integrity of your colon and vasculature. If you feel weaker when using the enema then use less DMSO. It might help some gut issues, but not most, contrary to what AMD implies, as I explained here. There are a number of other options that are more likely to help the gut, which I detail here.

  • Eyes: Research suggests dilute DMSO may offer relief for eye conditions like macular degeneration, cataracts, and floaters, based on anecdotal reports of improved vision and reduced symptoms. Urine is also extremely helpful for the eyes. I would combine 10% DMSO with fresh urine.

  • Dental problems: DMSO penetrates deeply to disinfect teeth and gums. combine with borax and glutamine for gum and enamel regeneration.

Circulatory problems: I once got angina that lasted for days after consuming too much erythritol (only after consuming it did the study come out showing it causes heart problems). I put 15mL DMSO into some juice and drank it, and the angina pain went away in a minute and never returned.


SIDE EFFECTS:

  • Skin Penetrant: only apply DMSO to clean skin

  • Astringent: 100% DMSO concentration will usually irritate skin on the top half of the body. If it causes itching, mix it with water or aloe vera if you can get the real aloe juice without chemicals. If you leave 100% DMSO on skin it can crenate it and then it takes a week to look plump again. If you put DMSO into a dry mouth it can burn the tissues. Make sure your mouth is moist.

  • Smell: DMSO causes you to smell like sulfur if you take enough. Some say that mixing it in milk or honey reduces or eliminates this (milk especially seems to work for me).

  • Interactions: DMSO is mostly safe with drugs unless it is taken at the same time as the drug, as it can then increase absorption and cause a dangerous spike.

    • On the other hand, DMSO is cholinergic, so it has additive effects with cholinergic drugs, although cannot find any anecdotes of this being a real issue. Make sure to supplement extra choline.

    • DMSO is also a blood thinner. Additive effects with blood thinner meds.

  • Beware sleep disturbance: Too much DMSO causes lack of sleep. Not quite “insomnia” because you may go to sleep just fine, but you might notice you wake up earlier than you should, not feeling sleepy anymore, as if you don’t need as much sleep as usual. But you do, and after a few days of less sleep you will really notice it catches up with you. How much is too much is hard to say, as it varies for each person, but just pay attention to how much you are sleeping. I would avoid taking DMSO at night for this reason also, but keep in mind it has a long half-life so if you dose it daily it will build up in your system. Btw, AMD also disputes this side effect, showing they have no clinical experience with it, but it’s proven in rats, and in myself. Try and see. Some people claim it helps them with sleep, but that’s because it is reducing whatever symptom they had that prevented them from sleeping. If you slept ok before DMSO then you will notice the difference.


DMSO References from AMD

Up until this ultimate reference post, the best I could point people to were the articles done by AMD. AMD is a team of anonymous people pretending to be a midwestern doctor. They do collect a lot of good info, but also some wrong info, so you have to be a bit careful with reading their stuff, but I still link to the articles because it’s a good starting place for research. The comments also contain many useful anecdotes (AMD pulled many of them from X), and from what I can tell they come from real people, so they are even more valuable, but less organized, than AMD’s info.

AMD’s Articles Include:
•Strokes, traumatic brain injuries, spinal cord injuries, developmental delay, Down Syndrome and many circulatory disorders.
•All types of pain, arthritis and acute or chronic tissue injuries (e.g., burns, scars and sprains).
•Autoimmune and connective tissue disorders.
•Many aspects of cancer (e.g., eliminating cancers and reducing the toxicity of conventional treatments) and how when mixed with a common dye, becomes a remarkably safe and effective cancer treatments.
•Eye, ear, sinus, and dental conditions (e.g., tinnitus and blindness).
•Internal organ disorders (e.g., pancreatitis and cirrhosis).
•A wide range of skin conditions.
•Acute and chronic infections including shingles and herpes.
•Respiratory issues (e.g., asthma, COPD, pulmonary fibrosis, cystic fibrosis).
•How DMSO can be combined with a wide range of pharmaceutical drugs, significantly increase their safety and ability to treat challenging conditions.
•How DMSO can be combined with a variety of natural substances to create homemade remedies for a myriad of difficult diseases.
Plus a history of the FDA’s unconscionable war against DMSO, the safety of DMSO, and over a thousand of reader testimonials on the remarkable benefits they’ve experienced from using DMSO.


My Ultimate Reference Collection


I have collected all of the main books on DMSO and fed them into Google Gemini Pro so that you can download the books and read them yourself if you have time, or you can ask Gemini some questions based on the synthesis of all that knowledge (including “tell me page numbers in the books to learn more about XYZ”). Note, you do need to already have a Gemini Pro subscription in order to ask questions, but even without a pro subscription you can see the summary of what it learned from all those books. This resource is only for paid subscribers:

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